Structure Generation
AI-based generative modeling and simulation to create stable protein structures.
Molecular Dynamics
Comprehensive Analysis Services
Comprehensive Analysis Services provides comprehensive analysis services that generate protein structures through AI-based protein structure prediction and modeling, evaluate stability under various conditions from various angles, analyze physicochemical properties in detail, and study intra- and inter-molecular interactions between proteins. This helps to provide a deep understanding of protein structure, stability, properties, and interactions.
Basic Analysis Services of Molecular Dynamics
Our MD Basic Analysis Services provide a robust foundation for understanding protein structure, stability, and dynamics,
enabling informed decision-making in research and drug development
Stability Analysis
Protein stability under various conditions, analyzing energy profiles.
Property Analysis
Key physicochemical properties like energy, temperature, and density in diverse environments.
Backbone Fluctuation
Tracks backbone movement to evaluate structural stability and variability.
Transition Analysis
Examines changes in secondary structure and interaction patterns in functional regions.
Interaction Analysis
Analyzes interactions between residues within a protein, focusing on structural stability and functional interactions.
Detail
Specialized Analysis Services
Utilizing advanced methods like binding affinity analysis, lipid dynamics, and immunogenicity assessment, we offer deep insights into protein structure and interactions to support research and drug development. Through SMD and umbrella sampling, we calculate binding energies and predict immune responses, ensuring safety and reliability.
Reference
Lee SY, Yoo HS, Han JH, Lee DH, Park SS, Suh MH, Lee JH, Oh SH, Choi BY , “Novel Molecular Genetic Etiology of Asymmetric Hearing Loss: Autosomal-Dominant LMX1A Variants” 2022, Ear and Hearing.
Lim HD, Lee SM, Yun YJ, Lee DH, Lee JH, Oh SH, Lee SY, “WFS1 autosomal dominant variants linked with hearing loss: update on structural analysis and cochlear implant outcome.” 2023, International Journal of Pediatric Otolaryngology.
Lee S, Yun Y, Cha JH, Han JH, Lee DH, Song JJ, Park MK, Lee JH, Oh SH, Choi BY, Lee SY, “Phenotypic and molecular basis of SIX1 variants linked to non-syndromic deafness and atypical branchio-otic syndrome in South Korea” 2023, Scientific Reports.
Lee SJ, Lee S, Han JH, Choi BY, Lee JH, Lee DH, Lee SY, Oh SH, “Structural analysis of pathogenic TMPRSS3 variants and their cochlear implantation outcomes of sensorineural hearing loss” 2023, Gene.
Cho SH, Yun Y, Lee DH, Cha JH, Lee SM, Lee J, Suh MH, Lee JH, Oh SH, Park MK, Lee SY, “Novel autosomal dominant TMC1 variants linked to hearing loss: insight into protein-lipid interactions.” 2023, BMC Medical Genomics.
